Patrick Street was located between Lonsdale and Little Lonsdale streets. On 12 February 1891, Gherson Visbord was charged with emptying night pans into Patrick Street. Police Constable John Campbell, in a police report, noted that he had seen
the defendant standing in the yard with a piece of paling in his hand which he had appeared to have been steering up the sewer which was full of night soil and waste paper and the water tap was running on it there was to night pans in the middle of the yard which had been recently emptied as they were both wet and there was night soil spilt in the yard in front of the closet doors.
In 1891, the Busy Bee Hotel as well as a number of other residents were located in Patrick Street. There were also two Catholic book importers and sellers located there. In 1900, Roeszley & Son Engravers were located in the street, and in 1910 the Labour Call was published from local premises.
In the 1980s the street was bought by the Melbourne Central shopping complex for $2.6 million.