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- Sabbatarianism (Sunday Observance)
- Sacré Coeur
- Salmon, Charles Carty (1860 - 1917), politician
- Salvation Army
- Sambell, Geoffrey Tremayne (1914 - 1980), Anglican archbishop
- Sampson Lane
- Samuel Lane
- Samuel Mauger Drinking Fountain
- Sanderson, John (1868 - 1945), businessman and grazier
- Sanderson, Robert Fitzroy (1889 - 1971), company director, grazier and manufacturer
- Sandown Park
- Sandown Racecourse
- Sandridge
- Sandridge Rail Bridge
- Sandringham
- Sarah Sands Hotel
- Sargood & Co.
- Sargood, Frederick Thomas (1834 - 1903), merchant and politician
- Sassafras
- Savage Club
- Savage, Robert (1818 - 1888), agricultural writer and inventor
- Save Our Sons
- Savoy Hotel (Hotel Alexander)
- Sayers, Charles Edward (1901 - 1979), historian and journalist
- Scantlebury, Lilian Avis (1894 - 1964), Red Cross worker
- School Banking
- School Medical Service
- School Physical Education
- Schutt, Helen Macpherson (1874 - 1951), philanthropist
- Science
- Science, Nature, Geography
- Scienceworks
- Scobie, James (1860 - 1940), horse-trainer
- Scoresby
- Scotch College
- Scots
- Scots' Church
- Scott Alley
- Scott, Ernest (1867 - 1939), historian
- Scott, Henry James Herbert (1858 - 1910), cricketer and physician
- Scotts Court
- Scott's Hotel
- Scratchley, Peter Henry (1835 - 1885), colonial administrator and military engineer
- Scrutator
- see Brady, Edwin James (1869 - 1952), journalist and writer
- Scrutator
- see Candler, Samuel Curtis (1827 - 1911), coroner
- Scullin, James Henry (1876 - 1953), grocer, newspaper editor and prime minister
- Sculpture and Memorials
- Seabrook
- Seabrook, Norman Hugh (1906 - 1978), architect
- Seabrook, Thomas Claudius (1886 - 1967), wine judge and wine merchant
- Seaford
- Seasons
- Secondary Teachers' College
- Sectarianism
- Seddon
- See Yup Temple
- Seitz, John Arnold (1883 - 1963), educationist
- Selby
- Selby, Isaac (1859 - 1956), historian and lecturer
- Self-Help Movements
- Selleck, Francis Palmer (1895 - 1976), accountant, businessman and lord mayor
- Separation
- Separation Memorial
- Serbs
- Serle, Percival (1871 - 1951), accountant and scholar
- Service Industries
- Service Stations
- Service, James (1823 - 1899), businessman and politician
- Sesquicentenary
- Seventh-Day Adventists
- Seville
- Sewell, Sidney Valentine (1880 - 1949), physician
- Sewerage
- Sex Ratio
- Sexton, Hannah Mary Helen (1862 - 1950), surgeon
- Shann, Edward Owen Giblin (1884 - 1935), economist
- Sharwood, William Henry (1872 - 1944), Commonwealth crown solicitor
- Shedden, Frederick Geoffrey (1893 - 1971), public servant
- Shenandoah
- Shenley
- Shepherd, Malcolm Lindsay (1873 - 1960), public servant
- Sherbrooke
- Sherlock, Wilfred Holden (Bill) (1908 - 1943), grazier and soldier
- Sherwood Place
- Shilling Lane
- Ship Inn
- Shipping
- Shipwrecks
- Shirlow, John Alexander Thomas (1869 - 1936), art teacher and etcher
- Shopping
- Shopping Malls
- Shops and Factories Act 1896
- Shore, Arnold Joseph Victor (1897 - 1963), artist and critic
- Shoreham
- Shrine of Remembrance
- Sidney Myer Music Bowl
- Siede, Julius (1825 - 1903), conductor and flautist
- Silvan
- Simmons, Roy Thomas (1906 - 1975), medical scientist
- Simonds, Justin Daniel (1890 - 1967), Catholic archbishop
- Simpson, George (1899 - 1960), gynaecologist and obstetrician
- Simson, Robert (1819 - 1896), pastoralist
- Sinapis
- see Neild, James Edward (1824 - 1906), drama critic, forensic pathologist, journalist and medical editor
- Sinclaire, Frederick (1881 - 1954), critic, professor, socialist and Unitarian minister
- Singaporeans
- Singleton, John (1808 - 1891), philanthropist and physician
- Sinnett, Frederick (1830 - 1866), journalist and literary critic
- Sir Edward 'Weary' Dunlop statue
- Sir John Monash Statue
- Sir Thomas Blamey Memorial
- Sir William Brunton Drinking Fountain
- Sir William John Clarke Statue
- Sissons, Alfred Thomas Stanley (1888 - 1975), chemist and college dean
- Sisters of Mercy
- Sisters of St Joseph
- Sisters of the Good Shepherd
- Six O'Clock Swill
- Skating
- Skene, Alexander John (1820 - 1894), government officer
- Skinner, Henry Hawkins (1851 - 1912), caterer, politician and sportsman
- Skipping Girl Sign
- Skurrie, Joseph (1858 - 1949), freethinker , goldminer and socialist
- Skye
- Skyscrapers
- Sladen, Douglas Brooke Wheelton (1856 - 1947), author
- Slater, William (1890? - 1960), politician and solicitor
- Sleigh, Hamilton Morton Howard (1896 - 1979), company director
- Sleights Lane
- Sluice (Sluys), Henry Vande
- see Rene, Roy (Mo) (1891 - 1954), comedian
- Slums
- Sly, Christopher
- see Neild, James Edward (1824 - 1906), drama critic, forensic pathologist, journalist and medical editor
- Smell
- Smith Street
- Smith, Alexander Kennedy (1824 - 1881), engineer
- Smith, Alfred Mica (Macaiah) (1844 - 1926), chemist and teacher
- Smith, Arthur Bruce (1851 - 1937), barrister, businessman and politician
- Smith, Christian Brynhild Ochiltree Jollie (1885 - 1963), solicitor
- Smith, Francis Grey (1827 - 1900), banker
- Smith, Helen
- see Schutt, Helen Macpherson (1874 - 1951), philanthropist
- Smith, Henry Teesdale (1858 - 1921), contractor and timber-miller
- Smith, Ivor Warne
- see Warne-Smith, Ivor Phillip Scharrer (1897 - 1960), Australian Rules footballer
- Smith, James (1820 - 1910), journalist
- Smith, John Thomas (1816 - 1879), landowner and publican
- Smith, Julian Augustus Romaine (1873 - 1947), photographer and surgeon
- Smith, Leslie
- see Fleetwood-Smith, Leslie O'Brien (1908 - 1971), cricketer
- Smith, Louise
- see Dyer, Louise Berta Mosson Hanson (1884 - 1962), music publisher and patron of the arts
- Smith, Norman Walter (1915 - 1973), Australian Rules football coach
- Smith, Ross Grey
- see Grey-Smith, Ross (1901 - 1973), racing administrator and solicitor
- Smith, Thomas (1823 - 1900), trade unionist
- Smith, William Howard (1814 - 1890), master mariner and ship-owner
- Smiths Gully
- Smorgons
- Smyth, Bridgetena (Brettena) (1840? - 1898), campaigner for women's health reform and women's political rights
- Smyth, Robert Brough (1830 - 1889), civil servant and mining engineer
- Smythe Lane
- Smythe, Robert Sparrow (1833 - 1917), entrepreneur and journalist
- Snider, Leon Samuel (1896 - 1965), entrepreneur, politician and theatre proprietor
- Sniders Lane
- Snowball, William (1854 - 1902), medical practitioner
- Snowden, Arthur (1829 - 1918), lawyer and politician
- Soccer
- Social Life & Customs
- Social Mobility
- Social Reform
- Social Work
- Socialism
- Society Five
- Soils
- Solly, Robert Henry (1883 - 1968), architect, businessman and lord mayor
- Solomon, Joseph
- see Thompson, Joseph (Joe) (1838 - 1909), bookmaker
- Somers
- Somerset Place
- Somerton
- Somerville
- Sorrento
- Sorrento Settlement
- South African War Memorial (aka Memorial To Fallen Soldiers, and Monument To The 5th Victorian Contingent)
- South Melbourne
- South Melbourne Football Club
- South Morang
- South Yarra
- Southbank
- Southern Cross Hotel
- Southern, Clara (1860 - 1940), artist
- Spanish
- Spark Lane
- Special Constables
- Spencer Street Station
- Spencer, Walter Baldwin (1860 - 1929), administrator, anthropologist, connoisseur and university scientist
- Spicer, John Armstrong (1899 - 1978), barrister, judge and politician
- Spiritualism and Mesmerism
- Spivakovsky, Jascha (1896 - 1970), pianist
- Sport & Recreation
- Sport, School
- Sport, University
- Sporting Culture
- Sports Grounds and Venues
- Spotswood
- Spotswood Pumping Station
- Spowers, Ethel Louise (1890 - 1947), painter and printmaker
- Springthorpe, John William (1855 - 1933), physician
- Springvale
- Squash
- Sri Lankans
- St Albans
- St Andrews
- St Augustine's Church
- St Clair, William Howard (1892 - 1977), estate, stock and station agent and soldier and estate
- St Columb's
- St Francis' Church
- St Francis Street
- St Helena
- St James Lane
- St James' Old Cathedral
- St James Street
- St Johns Lane
- St Kevin's College
- St Kilda
- St Kilda Botanical Gardens
- St Kilda Cemetery
- St Kilda Film Festival
- St Kilda Football Club
- St Kilda Road
- St Patricks Alley
- St Patrick's Cathedral
- St Patrick's College
- St Patrick's Day
- St Patrick's Hall
- St Paul's Cathedral
- St Peter's Eastern Hill
- St Vincent De Paul Orphanage
- St Vincent De Paul Society
- St Vincent's Hospital
- Stafford Lane
- Stained Glass
- Stanford Fountain
- Stanford, Thomas Welton (1832 - 1918), businessman, philanthropist and spiritualist
- Stanton, Byron Lionel (1891 - 1963), pharmacist and physician
- Stapley Memorial Drinking Fountain
- Stapley, Frank (1858 - 1944), architect and town planner
- Star Alley
- Star Lane
- State Bank Homes
- State Library of Victoria
- State Swimming Centre
- Statue Of Meditation
- Staughton Alley
- Staughton Place
- Stawell, Richard Rawdon (1864 - 1935), physician
- Stawell, William Foster (1815 - 1889), chief justice
- Steele, Bertram Dillon (1870 - 1934), professor of chemistry
- Steele, Clive Selwyn (1892 - 1955), army officer and engineer
- Steels Creek
- Stephen Street
- Stephen, James Wilberforce (1822 - 1881), judge and politician
- Stephens, Henry Douglas (1877 - 1952), paediatric surgeon
- Stephenson, Arthur George (1890 - 1967), architect
- Stevens, Duncan Herbert (1921 - 1964), naval officer
- Stevens, Edward (1858 - 1930), businessman and philanthropist
- Stevens, Horace Ernest (1876 - 1950), bass-baritone
- Stevenson Lane
- Stewart, Cam
- see Stewart, James Campbell (1884 - 1947), public servant and soldier
- Stewart, James Campbell (1884 - 1947), public servant and soldier
- Stillwell, Frank Leslie (1888 - 1963), geologist
- Stirling, Lorna Mary Belton (1893 - 1956), musicologist
- Stock Exchange
- Stokes, Harold Frederick (1899 - 1977), company director, engineer and hospital president
- Stone, Emma Constance (1856 - 1902), medical practitioner
- Stones, Ellis Andrew (1895 - 1975), garden designer
- Stonnington City
- Stony Point
- Storey Hall
- Storey, John Stanley (1896 - 1955), industrialist
- Strachan Lane
- Strachan, Hugh Murray (1851 - 1933), company director, pastoralist and woolbroker
- Strathmore
- Street Life
- Street Lighting
- Street Names
- Street Numbering
- Street Trees
- Streets & Lanes
- Stretch, Theodore Carlos Benoni (1817 - 1899), Anglican clergyman
- Stretton, Leonard Edward Bishop (1893 - 1967), judge and royal commissioner
- Strikes
- Strong, Archibald Thomas (1876 - 1930), man of letters, scholar and teacher
- Strong, Charles (1844 - 1942), clergyman
- Strong, Herbert Augustus (1841 - 1918), classicist and humanist
- Strutt, William (1825 - 1915), artist
- Stuart, Francis (Frank) (1844 - 1910), manufacturer and politician
- Stubbs Lane
- Student Radicalism
- Studley Park
- Studley Park Boathouse
- Sturdee, Vernon Ashton Hobart (1890 - 1966), army officer
- Styles, James (1841 - 1913), civil engineer, contractor and politician
- Suburbs & Localities
- Suburbs and Suburbanisation
- Suffrage
- Sugden Place
- Sugden, Edward Holdsworth (1854 - 1935), clergyman and educationist
- Suicide
- Sullivan, Thomas Barry (1821 - 1891), actor
- Sun News-Pictorial Newspaper
- Sun Theatre
- Sunbury
- Sunbury Pop Festival
- Sunday Schools
- Sunshine
- Sunshine Harvester Works
- Supermarkets and Grocers
- Supple, Gerald Henry (1823 - 1898), barrister, Irish patriot, journalist and poet
- Supreme Court
- Surf-Lifesaving
- Surgeons and Surgery
- Surrey Hills
- Surry Place
- Surveying
- Sutherland Street
- Sutherland, Alexander (1852 - 1902), journalist and schoolmaster
- Sutherland, Keith Leonard (1916 - 1980), industrial chemist
- Sutherland, Sulina Murray MacDonald (1839 - 1909), child welfare worker and nurse
- Sutherland, William (1859 - 1911), physical chemist and theoretical physicist
- Swallow & Ariell Ltd
- Swan, Andrew David (1896 - 1980), air force officer
- Swanson, Donald Alexander (1859 - 1940), builder
- Swanson, Victor George (1910 - 1972), engineer
- Swimming and Diving
- Swinburne University
- Swine Flu: In Focus - June 2009
- Sydenham
- Sydney
- Sydney Road
- Syme, David (1827 - 1908), newspaper proprietor
- Syme, David York (1876 - 1963), businessman
- Syme, Eveline Winifred (1888 - 1961), painter and printmaker
- Syme, Geoffrey (1873 - 1942), newspaper proprietor
- Syme, George Adlington (1859 - 1929), surgeon
- Symons, John Christian (1820 - 1894), clergyman
- Syndal
